Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications

📋 论文概要

该论文提出了一种自适应时钟升压和自动量程响应的神经刺激器，用于新兴的神经调控应用，如治疗难治性癫痫和阿尔茨海默病。通过自适应时钟升压技术提高刺激效率，自动量程机制确保在不同刺激需求下稳定工作。

💡 主要创新点

• 提出自适应时钟升压技术，动态调整时钟频率以优化刺激能量传输和效率。
• 实现自动量程响应机制，根据神经反馈自动调节刺激参数，增强治疗适应性。
• 集成于单芯片，实现低功耗和高可靠性，适用于植入式神经调控设备。

🏷 关键词

📄 原文摘要

David Groppe2, Xuan-Thuan Nguyen1, Karim Abdelhalim1, 3, Hamed Mazhab Jafari1,4, Taufik A. Valiante5, Peter Carlen5, Naveen Verma6, Roman Genov1 *1 *1 2 University of Toronto, Toronto, Canada Krembil Neuroscience Center, Toronto, Canada 3 now at Sitrus Technology, Irvine, CA 4 now at Envirosen, Toronto, Canada 5 Toronto Western Hospital, Toronto, Canada 6 Princeton University, Princeton, NJ *Equally-Credited Authors (ECAs) 1 2 An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer’s disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, non-invasive technology for closed-loop deep-brain neuromodulation (DBN) to treat neural disorders has been a holy grail of neuroscience for decades. Recent clinical studies of non-invasive

👥 作者与机构

M. Reza Pazhouhandeh , Gerard O'Leary , Iliya Weisspapir ,