A Cell-Capacitance-Insensitive CMOS Sample-and-Hold Chronoamperometric Sensor for Real-Time Measurement of Small Molecule Drugs in Whole Blood exponential model). Most of the signal-of-interest lies within the first 10ms after the potential stepping, indicating that the ADC can be further powered off during the other 90ms. The sensor front-end is configured to perform SWV calibration every few tens of minutes to track drift in the redox potential.

📋 论文概要

提出了一种对细胞电容不敏感的CMOS采样保持计时电流传感器，用于实时测量小分子。通过可调的满量程、积分电容和镜像比，将动态范围扩展了近40dB。

💡 主要创新点

• 采用三开关和反馈单位增益缓冲器构成的模拟保持器，有效减小泄漏电流，提高测量精度。
• 通过可调节的满量程（0.5-2µA）、积分电容（1b控制）和RGC镜像比（1:8），实现近40dB的动态范围扩展。
• 移除恒电位仪中的米勒补偿RC网络以避免不稳定性，同时采用尾电流320µA的电路结构优化功耗和性能。

🏷 关键词

📄 原文摘要

with a tail current of 320µA are employed in the DAC reference buffer, the current conveyor, and the potentiostat. The Miller-compensated RC network in the potentiostat is removed to avoid instability. To minimize leakage current, we implement an analog keeper using tri-switches and a feedback unity-gain buffer. Other circuits include a bandgap reference (BGR), a 10b R-2R DAC, and an FSM. The full scale (0.5-to-2µA) and the integrating capacitance (1b control) in the ADC, as well as the RGC mirror ratio (1:8) are made adjustable to expand the total dynamic range by nearly 40dB. Stanford University, Stanford, CA The capability of adjusting a drug-dosing profile in real time based on personalized pharmacokinetics plays a crucial role in achieving optimal therapeutic outcomes at minimal toxicity [1]. Achieving this requires biosensors that can continuously measure drug concentrations at sub-minute temporal resolution. Today, the gold

👥 作者与机构

Jun-Chau Chien, Hyongsok Tom Soh, Amin Arbabian, Figure 26.4.3 shows the circuit schematics. Two-stage Miller-compensated OTAs