A CMOS Multimodality In-Pixel Electrochemical and Impedance Cellular Sensing Array for Massively Paralleled Synthetic Exoelectrogen Characterization current/charge-transfer with CV and CA tests. The generated current from cell samples is integrated on the feedback capacitor (50 to 150fF) of the in-pixel capacitive-TIA (CTIA), and 2-point measurements extract the output integration slope to remove flicker noise and fixed pattern noise.

📋 论文概要

该论文提出了一种CMOS多模态像素内电化学和阻抗细胞传感阵列，用于大规模平行合成生物学应用。通过每个像素内的双工作电极结构，实现了高空间分辨率的阻抗传感，并集成了片上时钟发生器以产生正交信号。

💡 主要创新点

• 双工作电极像素内阻抗传感结构，支持多模态电化学与阻抗检测。
• 片上时钟产生I/Q信号，实现复阻抗测量与高空间分辨率。
• 大规模并行阵列设计，适用于合成生物学中的细胞分析。

🏷 关键词

📄 原文摘要

Sara Tejedor Sanz3, Sandra Grijalva4, Adam Wang1, Sensen Li1, Hee Cheol Cho4, Caroline Ajo-Franklin5, Hua Wang1 The complex cellular impedance sensing circuit is illustrated in Fig. 28.4.3. The two WEs in each pixel operate separately, with one (WE1) being used for in-phase voltage excitation (15 to 500kHz) and the other (WE2) for current sensing, enabling in-pixel impedance sensing between the two WEs with high spatial resolution. An on-chip clock generator produces Z-CLK/2 frequency I/Q signals and the in-phase voltage signal feeds the voltage excitation buffer to drive WE1. The resulting current flows through the cells into WE2 and is detected by a resistive-TIA (RTIA). The complex components of the cellular current are obtained by direct quadrature down-conversion. Georgia Institute of Technology, Atlanta, GA Intel, Hillsboro, OR 3 Lawrence Berkeley National Laboratory, Berkeley, CA 4

👥 作者与机构

Doohwan Jung1, Sagar Ramesh Kumashi1, Jongseok Park2,