A 64×64 Implantable Real-Time Single-ChargedParticle Radiation Detector for Cancer Therapy

📋 论文概要

该论文提出了一款64×64像素的植入式实时单带电粒子辐射探测器，用于癌症治疗中的质子束监测。通过检测单个带电粒子，实现了对布拉格峰位置的精确追踪，从而优化辐射剂量分布并保护周围健康组织。

💡 主要创新点

• 首次实现64×64像素阵列的植入式单粒子实时探测，能够追踪单个带电粒子以确定布拉格峰位置。
• 采用低功耗设计，适用于体内植入，并能在高辐射环境下稳定工作。

🏷 关键词

📄 原文摘要

Kavita K. Mishra2, Bruce A. Faddegon2, Michel M. Maharbiz1, Mekhail Anwar2 University of California, Berkeley, CA 2 University of California, San Francisco, CA 1 60% of all cancer treatment requires radiation therapy and the fundamental goal is to deposit sufficient energy in a tumor to irreparably damage its DNA. Unlike high energy photons which pass through the body, charged particles such as protons deposit the majority of their energy at a specific depth, the location of the Bragg peak. In theory, this allows high radiation doses to be delivered in submm proximity to critical organs such as the spinal cord (see Fig. 34.1.1). Unfortunately, mm-scale prediction of the in vivo Bragg peak location is challenging because particle energy loss and scattering are highly path-dependent and patient-specific, largely due to anatomical heterogeneity which drifts from day to day. Given this, clinicians usually reduce therapeutic doses or adjust

👥 作者与机构

Kyoungtae Lee1, Jessica Scholey2, Eric B. Norman1, Inder K. Daftari2,