An Optically-Addressed Nanowire-Based Retinal Prosthesis with 73% RF-to-Stimulation Power Efficiency and 20nC-to-3µC Wireless Charge Telemetering

📋 论文概要

本文提出了一种基于纳米线的光学寻址视网膜假体，解决了传统视网膜假体中可单独刺激像素数量受限的问题。该假体实现了73%的RF到刺激功率效率，并支持20nC至3µC的刺激电荷范围。

💡 主要创新点

• 采用光学寻址方式替代传统有线或无线寻址，提高了像素密度和刺激精度。
• 利用纳米线电极实现高效电荷注入，同时保持低功耗和高功率效率。
• 系统级设计优化了RF能量传输与刺激电路，达到73%的RF-to-stimulation效率。

🏷 关键词

📄 原文摘要

Patrick P. Mercier1, Gert Cauwenberghs1 University of California, San Diego, La Jolla, CA KAIST, Daejeon, Korea 3 Nanovision Biosciences, San Diego, CA 1 2 Recent approaches toward a functional retinal prosthesis to restore vision in neurodegenerative patients have been limited by the number of pixels that can be individually stimulated. The conventional approach, shown in Fig. 18.1.1 (left), uses an external camera to capture video, whose information is then wirelessly delivered to a hermetic housing (typically a titanium can) for conversion to N distinct stimulation pulses fed transocularly to an N-channel microelectrode array (MEA) placed epi- or subretinally. While this approach has proven long-term biocompatibility, translation to 1000s of channels with hermetic and durable transocular connections is not achievable with current technology, limiting existing designs to at most 256 channels, barely sufficient

👥 作者与机构

Abraham Akinin1, Jeremy M. Ford1, Jiajia Wu1, Chul Kim2, Hiren D. Thacker3,