CMOS-Driven Pneumatic-Free Scalable Microfluidics and Fluid Processing with Label-Free Cellular and Bio-Molecular Sensing Capability for an End-to-End Point-of-Care System

📋 论文概要

该论文提出了一种基于CMOS驱动的无气动、可扩展微流控平台，用于无标签细胞和生物分子传感，旨在解决低成本便携式分子诊断中样品处理、过滤、混合等瓶颈问题。

💡 主要创新点

• 利用CMOS电路直接驱动微流控操作，无需传统气动装置，降低系统复杂度和成本。
• 实现可扩展的微流控架构，支持高通量并行处理生物样品。
• 采用无标签传感技术，简化检测流程并提高灵敏度。

🏷 关键词

📄 原文摘要

point-of-care (POC) molecular diagnostic platforms that encompass an end-to-end system (from sample fluid to diagnostic information) with the ability to allow rapid analysis on the spot. While POC sensing technologies have been demonstrated in miniaturize chip-scale platforms [1-5], the bottlenecks in enabling end-to-end low-cost handheld platforms have often been bio-sample handling, filtering, mixing with re-agents that are critical to the robustness of the assay chemistry and sensing sensitivity/specificity. These processes are typically carried out either manually or by employing complex pneumatic flow control with multiple bulky syringe pumps, which have been a severe limitation to enable endto-end biosensing systems (Fig. 18.2.1). While electrically driven droplets, molecular and cell manipulation techniques, such as electro-wetting, electrophoresis and

👥 作者与机构

Chengjie Zhu, Jesus Maldonado, Hao Tang, Suresh Venkatesh, Kaushik Sengupta

Princeton University, Princeton, NJ The emergence of the pandemic has demonstrated the necessity of