⚡ 本页包含 AI 生成的分析内容,仅供参考
该论文提出了一种基于MEMS的动态光聚焦系统,用于光遗传学中实现单细胞精度的神经刺激。该系统通过MEMS驱动的微镜阵列实现光束的快速扫描和聚焦,解决了传统植入式LED或光纤照明范围广、缺乏光束转向能力的问题。
Mohammad Meraj Ghanbari1, Nick Antipa1, Sina Faraji Alamouti1, Laura Waller1,2, Daniel Lopez3, Rikky Muller1,2 University of California, Berkeley, CA Chan Zuckerberg Biohub, San Francisco, CA 3 National Institute of Standards and Technology, Gaithersburg, MD 1 2 Optogenetics is a technique that involves the use of light to excite or inhibit neurons that have been genetically modified to express light-sensitive ion channels (opsins). Implanted LEDs or optical fibers are the most common approaches in optogenetic stimulation systems, but their broad illumination and lack of beam steering capability make them insufficient for probing individual neurons. When a 3D scanning optical system is used to control the position of a laser spot, single-cell precision can be achieved in a volume of tissue containing millions of cells. Due to the sub-ms response time of modern opsins and a demand for high throughput neural stimulation [1], a
Cem Yalcin1, Nathan Tessema Ersumo1, George Bocchetti1,