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ISSCC 2021Session 19 · OPTICAL SYSTEMS FOR EMERGING APPLICATIONSWireline I/O

A MEMS-Based Dynamic Light Focusing System for Single-Cell Precision in Optogenetics

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📋 论文概要

该论文提出了一种基于MEMS的动态光聚焦系统,用于光遗传学中实现单细胞精度的神经刺激。该系统通过MEMS驱动的微镜阵列实现光束的快速扫描和聚焦,解决了传统植入式LED或光纤照明范围广、缺乏光束转向能力的问题。

💡 主要创新点

重要性
发表年份
ISSCC 2021

🏷 关键词

MEMS光遗传学动态光聚焦单细胞精度微镜阵列

📄 原文摘要

Mohammad Meraj Ghanbari1, Nick Antipa1, Sina Faraji Alamouti1, Laura Waller1,2, Daniel Lopez3, Rikky Muller1,2 University of California, Berkeley, CA Chan Zuckerberg Biohub, San Francisco, CA 3 National Institute of Standards and Technology, Gaithersburg, MD 1 2 Optogenetics is a technique that involves the use of light to excite or inhibit neurons that have been genetically modified to express light-sensitive ion channels (opsins). Implanted LEDs or optical fibers are the most common approaches in optogenetic stimulation systems, but their broad illumination and lack of beam steering capability make them insufficient for probing individual neurons. When a 3D scanning optical system is used to control the position of a laser spot, single-cell precision can be achieved in a volume of tissue containing millions of cells. Due to the sub-ms response time of modern opsins and a demand for high throughput neural stimulation [1], a

👥 作者与机构

Cem Yalcin1, Nathan Tessema Ersumo1, George Bocchetti1,

分类:Wireline I/O · 年份:ISSCC 2021