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本文提出了一种可重构子阵列复用的微电极阵列系统,集成了24,320个电极和380个读出通道,用于研究大脑中单个神经元和突触的电活动。该系统解决了传统成像和标记方法无法覆盖大面积细胞分布的问题。
Ji-Hyoung Cha1, Jee-Ho Park1, Yongjae Park1, Hyogeun Shin2, Kyeong Seob Hwang2, Il-Joo Cho2, Seong-Jin Kim1 Ulsan National Institute of Science and Technology, Ulsan, Korea Korea Institute of Science and Technology, Seoul, Korea 1 2 It is crucial to investigate electrical activities from a single neuron and neuronal synapses in electrophysiology for brain research. Conventional physiological tools such as imaging and labeling are insufficient to cope with neural signals from cells distributed over a large area [1]. Microelectrode array (MEA) systems featuring high-density electrodes and lownoise analog front-ends (AFE) have been representative solutions to acquire intracellular and extracellular potentials from in vitro multiple neurons [2-7]. Although the number of electrodes in MEA systems and their spatial resolution are increased thanks to advances in CMOS technology, they still suffer from area constraints in the low-noise
Array System with 24,320 Electrodes and 380 Readout, Channels for Investigating Neural Communication