A 65nm CMOS Living-Cell Dynamic Fluorescence Sensor with 1.05fA Sensitivity at 600/700nm Wavelengths

📋 论文概要

本文提出了一种基于65nm CMOS工艺的活细胞动态荧光传感器，能够检测600/700nm波长的微弱荧光信号，灵敏度达到1.05fA。该传感器旨在实现低成本、微型化的临床生物标志物检测，适用于即时诊断和连续健康监测。

💡 主要创新点

• 首次在65nm CMOS工艺中实现fA级（1.05fA）荧光检测灵敏度，突破了传统光学检测的复杂性和成本限制。
• 设计针对600/700nm特定波长的动态荧光传感方案，适用于常见生物标记物的高灵敏检测。
• 集成微型化传感前端，无需外部复杂光学设置，可用于活细胞实时监测。

🏷 关键词

📄 原文摘要

Richard M. Murray1, Azita Emami1 California Institute of Technology, Pasadena, CA Texas A&M University, College Station, TX 1 2 Integrated, low-cost and miniaturized devices that can detect clinically relevant biomarkers are crucial for the growing field of precision medicine as they can enable point-of-care diagnosis, continuous health monitoring and closed-loop drug delivery. Fluorescence (FL) sensing is known to be one of the most reliable, sensitive, and widely adopted sensing modality for many biomarkers [1,3]. However, detecting the weak FL signal requires complex optical setups, especially narrowband optical filters to block the strong excitation (EX) light. Prior efforts [1] to miniaturize and implement FL sensing in CMOS technologies have been limited to on-chip high-pass filters using dense vertical waveguide arrays. More importantly, the reported wavelength range of 800nm in [1] is

👥 作者与机构

Fatemeh Aghlmand1, Chelsea Hu1,2, Saransh Sharma1, Krishna K. Pochana1,