A CMOS Multi-Functional Biosensor Array for Rapid LowConcentration Analyte Detection with On-Chip DEP-Assisted Active Enrichment and Manipulation with No External Electrodes

📋 论文概要

该论文提出了一种基于CMOS工艺的多功能生物传感器阵列，用于快速检测低浓度分析物。通过片上介电泳（DEP）辅助主动富集，解决了传统生物传感器中表面生物受体固定困难和超痕量检测质量传输受限的问题。

💡 主要创新点

• 提出了一种集成片上DEP的主动富集技术，能够在传感器界面快速捕获低浓度分析物，突破质量传输限制。
• 采用CMOS工艺实现了多功能生物传感器阵列，可同时进行多种分析物检测，提升检测效率。
• 通过电路与微流控系统的协同设计，实现了快速、高灵敏度的低浓度检测，无需外部放大或复杂信号增强步骤。

🏷 关键词

📄 原文摘要

Diego, CA 1 3 Electronic biosensors are transducers that convert biomolecular or cellular information to electronic readouts. Though advances in electronics keep improving biosensors’ performance, often their ultimate detection limits and functionalities are constrained at the sensor interfaces. For instance, existing electrochemical or optical bioanalytical platforms commonly face challenges in immobilizing surface bioreceptors and detecting ultra-trace biospecimens due to the slow mass transport limitation from the bulk solution. Additional target amplification or complex signal enhancement are thus needed. Therefore, there is a perennial need to explore biology-electronics co-designs to overcome some of these interface limitations and further advance biosensor detection

👥 作者与机构

Dongwon Lee1, Doohwan Jung2, Fuze Jiang1, Gregory Villiam Junek3,

Jongseok Park4, Hangxing Liu1, Ying Kong1, Youngin Kim1, Jing Wang1, Hua Wang1,3 ETH Zürich, Zurich, Switzerland, 2Qualcomm, San Jose Georgia Institute of Technology, Atlanta, GA, 4Apple, San