A Fully Integrated End-to-End Genome Analysis Accelerator for Next-Generation Sequencing

📋 论文概要

本文提出了一款全集成端到端基因组分析加速器，用于下一代测序，实现了高吞吐量低功耗的基因数据分析，解决了传统软件分析速度慢的问题。

💡 主要创新点

• 实现了首个全集成端到端基因组分析加速器，覆盖测序数据处理的完整流程
• 采用高效的硬件架构和并行化设计，显著提升分析吞吐量并降低功耗
• 针对不同基因组分析步骤优化了数据流和存储，减少了片外数据访问

🏷 关键词

📄 原文摘要

Wen-Ching Chen3, Liang-Yi Lin3, Nian-Shyang Chang3, Chun-Pin Lin3, Chi-Shi Chen3, Jui-Hung Hung2,4, Chia-Hsiang Yang1,2 National Taiwan University, Taipei, Taiwan GeneASIC Technologies, Hsinchu, Taiwan 3 Taiwan Semiconductor Research Institute, Hsinchu, Taiwan 4 National Yang Ming Chiao Tung University, Hsinchu, Taiwan *Equally Contributing Authors (ECA) 1 2 Next-generation sequencing (NGS) has revolutionized biological sciences and clinical practices. It has become an essential technology for various emerging applications, such as cancer screening and inherited disease diagnosis. Fig. 2.4.1 shows an overview of an NGS pipeline. An NGS pipeline includes sample preparation, sequencing, data analysis and tertiary analysis. A sequencer first generates a massive amount of DNA segments (short-reads) from samples. Short-reads are used as the inputs for data analysis. The outputs (genetic variants) of the data analysis can then be sent to facilities for further

👥 作者与机构

Yen-Lung Chen*1, Chung-Hsuan Yang*1, Yi-Chung Wu*1, Chao-Hsi Lee2,