A Miniature Multi-Nuclei NMR/MRI Platform with a High-Voltage SOI ASIC Achieving a 134.4dB Image SNR with a 173×250×103µm3 Resolution

📋 论文概要

该论文提出了一种微型多核NMR/MRI平台，集成高压SOI ASIC，实现了134.4dB的图像信噪比。解决了传统MRI设备体积大、成本高的问题，可同时进行1H/19F多核成像，用于分子诊断和治疗监测。

💡 主要创新点

• 首次实现微型化多核NMR/MRI平台，尺寸仅173×250×103µm³。
• 采用高压SOI ASIC，在极小体积内实现高图像SNR（134.4dB）。
• 支持1H/19F双核成像，无需额外外部设备，简化系统复杂度。

🏷 关键词

📄 原文摘要

Instituto Superior Técnico/Universidade de Lisboa, Lisbon, Portugal 1 2 Magnetic resonance imaging (MRI), based on Nuclear Magnetic Resonance (NMR), is an indispensable tool for contemporary medicine. Moreover, the advent of multi-nuclei MRI imaging, such as 1H/19F imaging using perfluorocarbon (PFC) nanoparticles, can detail anatomical and molecular information in a single session. It has revolutionized the field of molecular diagnostics and therapy monitoring by offering unprecedented insights into the physiological and pathological processes. While 1H MRI can reveal the object’s anatomy, the ubiquitous presence of 1H in biological materials hinders effectiveness in tracking specific substances within the body (e.g., targeted drug delivery). Contrarily, as natural 19F is rare inside the body, it can serve as a marker for tracing substances with high specificity, thereby providing an accurate measure of the disease’s extent or

👥 作者与机构

Shuhao Fan1, Qi Zhou1, Ka Meng LEI1, Rui P. Martins1,2, Pui-In Mak1

University of Macau, Macau, China