Fully Integrated CMOS Ferrofluidic Biomolecular Processing

📋 论文概要

本文提出了一种全集成CMOS铁磁流体生物分子处理平台，能够在芯片上实现液滴的操控、多路复用和传感功能，解决了传统生物分子处理平台集成度低、控制复杂的问题。该平台利用铁磁流体实现高效液滴驱动，为大规模生物分子处理提供新方案。

💡 主要创新点

• 首次将铁磁流体技术集成到CMOS芯片上，实现片上液滴的精确操控和传感。
• 集成了液滴多路复用功能，支持大规模生物分子并行处理。
• 采用CMOS工艺实现完全集成的生物分子处理平台，无需外部设备。

🏷 关键词

📄 原文摘要

Dongwon Lee*1, Kyung-sik Choi*1, Fuze Jiang*1, Hangxing Liu1, Doohwan Jung2, Ying Kong1, Marco Saif1, Zhikai Huang1, Jing Wang1, Hua Wang1 ETH Zürich, Zurich, Switzerland Qualcomm, Santa Clara, CA *Equally Credited Authors (ECAs) 1 2 Biomolecules govern almost all the biochemical and biological processes, including storing/transmitting genetic codes and altering cellular activities. There is a perennial need for instrumentation platforms that can process large libraries of biomolecules with high multiplexing, finely controlled conditions, and capabilities of sensing, actuation, and even synthesis of biomolecules. In the past decades, CMOS integrated circuit (IC) platforms are gaining increasing traction for biomolecular and cellular applications due to their unparalleled integration and versatile sensing/actuation abilities. Taking DNAs as an example of biomolecules, their nucleotide sequences encode the

👥 作者与机构

Platform with On-Chip Droplet-Based Manipulation, Multiplexing and Sensing