Reversing Scattering to Perform Deep-Tissue Optical Imaging and the Current Need for a Suitable Optoelectronic Solution Changhuei Yang

📋 论文概要

该论文提出通过逆转散射实现深层组织光学成像，解决了传统光学成像因组织散射导致穿透深度不足1毫米的问题。

💡 主要创新点

• 提出逆转散射方法，突破传统光学成像在生物组织中的散射限制
• 将光学成像与光电子解决方案结合，实现深层组织高分辨率成像

🏷 关键词

📄 原文摘要

is on the order of 100 microns. This extreme turbidity prevents scientists and clinicians from performing deeply penetrating high resolution optical imaging through humans and animal models alike. The challenge associated with deep-tissue optical imaging is akin to the challenge of focusing light through a dense fog – scattering prevents meaningful solutions to this problem by traditional means. This is why high-resolution optical imaging and optical excitation methods cannot reach more than 1 mm into biological tissues. Deep penetrating imaging modalities, such as x-ray imaging, MRI, and ultrasound imaging, are excellent at revealing structures within biological entities, but provide no biochemical detection capability. On the other hand, there is a wide variety of optical domain methods capable of revealing biochemical content, including fluorescence, harmonic generation, Raman spectroscopy and absorption spectral signatures. If we can overcome optical tissue

👥 作者与机构

California Institute of Technology, Pasadena, CA, Biological tissues are highly turbid in the optical regime – the mean optical scattering length