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ISSCC 2025Session 20 · SENSORS AND ACTUATORS FOR HEALTH & AUTONOMYMedical & Bio

Millimeter-Sized 0.1pM LoD Wireless 16-Channel Organic-Electrochemical-Transistor-Based Electrochemical Sensing SoC

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📋 论文概要

该论文提出了一种毫米级尺寸、0.1 pM检测限的无线16通道有机电化学晶体管电化学传感SoC,用于长期监测细胞因子等生物标志物,解决了微型化植入式传感器高灵敏度、宽动态范围和空间分辨率的挑战。

💡 主要创新点

核心指标
0.1 pM LoD, 16-channel, wireless
重要性
发表年份
ISSCC 2025

🏷 关键词

电化学传感SoC有机电化学晶体管无线植入式传感器细胞因子检测毫米级

📄 原文摘要

such as TNF-alpha and IL-6, play a crucial role as biomarkers in the management of chronic diseases like autoimmune disorders, cardiovascular diseases, and cancer [1]. Since long-term monitoring of these cytokines is essential for an effective disease management, miniaturized electrochemical sensor implant systems offer a less invasive option for monitoring of substance concentrations within the human body [2] [3]. However, it remains a challenge to develop an electrochemical implant system that offers high sensitivity, a wide dynamic range (DR), and a certain level of spatial resolution for detecting inflammatory factors. Existed electrochemical sensing solutions rely on threeelectrode (3E) systems or Ion-Sensitive Field-Effect Transistors (ISFETs) [4-7]. The surface

👥 作者与机构

Yuan Ma*1, Shangbin Liu*1, Yahao Song1, Chao Xie1, Yuwei Zhang2, Chao Sun2,

Xiaoyan Ma2, Lan Yin1, Milin Zhang1 Tsinghua University, Beijing, China Beijing Ningju Technology, Beijing, China 1 2 *Equally Credited Authors (ECAs) Inflammatory cytokines,

分类:Medical & Bio · 年份:ISSCC 2025