A Fully Integrated GMR Biosensor with On-Chip Coils and Sensors Achieving 605 Resolution FoM for Multiplexed PoC Diagnostics

📋 论文概要

本文提出一种全集成GMR生物传感器芯片，集成片上传感器、励磁线圈和数字后端，实现高灵敏度、低噪声和快速读取，用于多路复用即时诊断，解决了传统GMR传感器外部线圈大、读取慢、集成度低的问题。

💡 主要创新点

• 首次实现全集成片上励磁线圈与GMR传感器，无需外部线圈，大幅缩小系统体积
• 采用数字后端实现21倍更快的读出速度和10倍更低的基线噪声，分辨率FoM达605，优于先前设计

🏷 关键词

📄 原文摘要

Abstract This paper presents a fully integrated GMR biosensor chip for point-of-care in vitro diagnostics featuring on-chip sensors, excitation coils, and a digital back-end. The system achieves 120nTrms noise, 0.38ppm sensitivity, <0.2% mismatch, and a resolution FoM of 605, outperforming prior GMR designs with 21× faster readout and 10× lower baseline with full integration. Real-time IL-6 immunoassay results demonstrate high specificity and multiplexing, enabling compact, high-throughput PoC testing. Point-of-care (PoC) diagnostics are increasingly vital for rapid, decentralized healthcare, enabling timely decision-making in settings ranging from clinics to resource-limited environments. The COVID-19 pandemic accelerated their adoption worldwide, underscoring the value of portable, cost-effective tools that deliver laboratory-quality results anywhere. Simple colorimetric methods (e.g., lateral flow assays commonly used for pregnancy tests)

👥 作者与机构

Mengze Wu1, Remy Lassalle-Balier2, Pablo Aguirre3, Florencia Ferrer3, Sina Haji Alizad4, Shekher Kummari1, Alex Latham4, Drew A. Hall1

University of California, San Diego, CA, 2Allegro MicroSystems, Chavanod, France, 3Allegro MicroSystems, Montevideo, Uruguay, 4Allegro MicroSystems, Manchester, NH