Abstract The paper presents a 256-channel solid-state nanopore readout IC in 65nm CMOS. A new integrate-and-hold TIA cuts per-pore power and area >6× while achieving 1MHz BW and 193pArms at 10nA. Event detection with dynamic slot allocation exploits sub-1 percent activity to reduce ADC data 32×. The chip delivers 1mW and 0.019mm2 per pore and records labeled DNA translocations, enabling scalable, low-cost single-molecule diagnostics. Nanopore single-molecule sensing holds great promise for enabling affordable personalized healthcare and medical diagnostics [1]. Reducing the cost of such diagnostic tools opens new application domains, including preventive cancer screening and the development of patient-specific therapies. While large biological nanopore arrays have already been deployed in commercial platforms, solid-state nanopores can provide larger signal amplitudes, enabling faster readouts per pore. This capability is critical for improving the
Sander Crols1,2, Carolina Mora Lopez2, Filip Tavernier1, Marian Verhelst1,2, Nick Van Helleputte2
KU Leuven - MICAS, Leuven, Belgium, 2imec, Leuven, Belgium