Shape-Memory Multi-Size Micro-Cage Array on CMOS with Integrated Electrochemical Sensors for Joint Bio-Sample Manipulation and Sensing

📋 论文概要

本文提出了一种CMOS集成的形状记忆多尺寸微笼阵列，结合多材料电化学恒电位仪，实现了无电源固定和多路复用传感，解决了现有Lab-on-CMOS平台在联合传感-操控能力上的不足，推进了多尺度生物样本培养与监测。

💡 主要创新点

• 首次在CMOS上集成形状记忆多尺寸微笼阵列，实现无电源的样本固定与释放。
• 集成多材料电化学恒电位仪，支持多路复用传感，提升检测通量。
• 将传感与操控功能单片集成，无需外部设置，适用于生理介质中的多尺度生物样本。

🏷 关键词

📄 原文摘要

Abstract Lab-on-CMOS platforms require joint sensing–manipulation capabilities for biosamples from single cells to organoids. Existing methods such as DEP, optical, and acoustic tweezers need external setups, continuous power, and face limitations in physiological media. We present a CMOS-integrated shape-memory multi-size micro-cage array with multi-material electrochemical potentiostats, enabling power-free immobilization and multiplexed sensing, advancing multiscale biosample culture and monitoring. Lab-on-CMOS systems increasingly need on-chip multifunctional joint sensing-manipulation capabilities to address complex biological samples from single cells to multicellular structures. For instance, organoids as miniaturized in vitro 3D cellular models widely used in drug discovery, disease modeling, and regenerative medicine, often require reliable onchip immobilization to ensure stable growth, reproducible measurements, and optimal

👥 作者与机构

Zhikai Huang, Fuze Jiang, Hangxing Liu, Adam Wang, Yuguo Sheng, Marco Saif, Hua Wang

ETH Zurich, Zurich, Switzerland