⚡ 本页包含 AI 生成的分析内容，仅供参考
该论文提出了一种混合光遗传刺激系统，通过亚阈值电刺激降低光学阈值并减少能耗，实现了90.75%的LED驱动效率和70.6%的光学能量节省。该系统利用高效电容充放电操作产生衰减指数辐照度，增强神经响应，并在小鼠离体实验中验证了等效神经激活。
Abstract This work presents a hybrid optogenetic stimulation system with sub-threshold electrical stimuli that lower the optical threshold and reduce energy consumption. It achieves 90.75% LED driving efficiency through efficient capacitor charge–discharge operation and generates decaying-exponential irradiance to enhance neural responses. Ex vivo experiments in mice validate equivalent neural activation with a 70.6% optical energy saving compared to conventional optogenetics. Neural stimulation has been extensively studied in implantable medical devices for treating neurological disorders. Conventional neural stimulation has utilized electrical stimuli, but stimulation current may lead to unintended neural activation due to stimulus artifact, resulting in poor spatial selectivity [1]. To overcome this limitation, optogenetic stimulation has been studied to enable cell-specific activation and high selectivity [2]. Nevertheless,
Joonghoon Kang1, Hyeonhee Roh2, Kyeongho Eom1, Hyun-Su Lee1, Hojae Chon1, Maesoon Im2, Hyung-Min Lee1
Korea University, Seoul, Korea, 2Korea Institute of Science and Technology, Seoul, Korea