A CMOS Neural Probe with 1280 Electrodes and 88 Emission Sites Featuring Thermo-Optic Switching and On-Chip Calibration for Dual-Wavelength Optogenetics

📋 论文概要

提出了一种基于双层硅光子学的CMOS神经探针，集成了1280个电极、384个记录通道和88个光发射位点，通过热光开关和片上校准实现大规模、可靠的光遗传学记录与刺激。解决了现有神经探针在通道数量和光发射集成度上的瓶颈问题。

💡 主要创新点

• 采用双层硅光子学与CMOS电路集成，实现了1280个电极和88个发射位点的大规模神经接口。
• 引入热光开关和定制光子驱动IC，配合片上光电二极管和温度传感器进行实时校准和热监测。

🏷 关键词

📄 原文摘要

Harrie A. C. Tilmans, Anabel De Proft, Barundeb Dutta, Carolina Mora Lopez imec, Heverlee, Belgium *Equally Credited Authors (ECAs) Abstract We present a waveguide-based optogenetics neural probe with 1,280 electrodes, 384 recording channels, and 88 emission sites enabled by dual-layer silicon photonics. Thermooptic switches are controlled by a custom photonic driver IC, while integrated tap couplers with photodiodes and a temperature sensor provide on-chip calibration and thermal monitoring. The probe achieves a large number of recording and emission sites, enabling reliable large-scale, cell-type-specific optogenetic studies. Studying brain function at the single-cell level requires tools that offer both high-resolution recording and cell-type specificity [1]. High-density CMOS neural probes [2-5] provide excellent spatiotemporal resolution for recording neuronal activity but lack the ability to

👥 作者与机构

Xiaolin Yang*, Pieter Neutens*, Alexis Humblet, Chutham Sawigun, John O’Callaghan, Thijs Geurts, Zheyi Li, Yaroslav Gubin, Koen De Munck,