ISSCC 2013
Session 16
Medical & Bio
A 20μW Intra-Cardiac Signal-Processing IC with 82dB Bio-Impedance Measurement Dynamic Range and Analog Feature Extraction for Ventricular Fibrillation Detection
of multiple intra-cardiac signals is becoming more and more important for Cardiac Resynchronization Therapy (CRT) and for the analysis of the intra-thoracic fluid status [1, 2]. Robust and accurate Heart-Rate (HR) monito
ISSCC 2013
Session 16
Medical & Bio
An Integrated Magnetic Spectrometer for Multiplexed Biosensing
There is high demand for at-home and point-of-care medical diagnostic tools as a step toward fast, low-cost, personal medicine. Integrated biosensors based on magnetic labeling schemes offer higher sensitivity and lower
ISSCC 2013
Session 16
Medical & Bio
A Near-Field-Communication (NFC) Enabled Wireless Fluorimeter for Fully Implantable Biosensing Applications
that enable long-term implantation can facilitate treatments for a variety of diseases and conditions [1,2]. This type of sensor system can also build off the standards used in near-field communications, which provide a
ISSCC 2013
Session 16
Medical & Bio
A Fully Intraocular 0.0169mm2/pixel 512-Channel Self-Calibrating Epiretinal Prosthesis in 65nm CMOS
Han-Chieh Chang1, Yu Zhao1, James Weiland2,3, Mark Humayun2,3, Yu-Chong Tai1, Azita Emami-Neyestanak1 California Institute of Technology, Pasadena, CA, Doheny Eye Institute, Los Angeles, CA, 3 University of Southern Cali
ISSCC 2013
Session 16
Medical & Bio
A 37.6mm2 1024-Channel High-Compliance-Voltage SoC for Epiretinal Prostheses
Retinal implants elicit light perception for people blinded by photoreceptor loss. Commercialized 60-channel retinal prostheses allow patients to perform simple tasks, but several hundreds to a thousand electrodes are re
ISSCC 2013
Session 16
Medical & Bio
24-Channel Dual-Band Wireless Neural Recorder with Activity-Dependent Power Consumption
activity from freely behaving animals has become extremely important for basic research in neuroscience. One of the major limitations in this domain arises from the need of a low-power, lightweight, wireless recording un
ISSCC 2013
Session 16
Medical & Bio
A 0.45V 100-Channel Neural-Recording IC with Sub-μW/Channel Consumption in 0.18μm CMOS
Conventional neural-recording systems face limitations in simultaneously achieving a good NEF and low power consumption [1-4]. This is because the input amplifier current consumption is dictated by an input-referred nois
ISSCC 2013
Session 16
Medical & Bio
An Implantable 455-Active-Electrode 52-Channel CMOS Neural Probe
Marleen Welkenhuysen1, Wolfgang Eberle1, Carmen Bartic2, Robert Puers2, Refet Firat Yazicioglu1, Georges Gielen2 imec, Heverlee, Belgium, 2KU Leuven, Heverlee, Belgium 1 Several studies have demonstrated that understandi
ISSCC 2013
Session 16
Medical & Bio
A Fully Integrated 8-Channel Closed-Loop Neural-Prosthetic SoC for Real-Time Epileptic Seizure Control
Chi Jeng1, Shun-Ting Chang1, Ming-Dou Ker1, Chun-Yu Lin1, Ya-Chun Huang1, Chia-Wei Chou1, Tsun-Yuan Fan1, Ming-Seng Cheng1, Sheng-Fu Liang2, Tzu-Chieh Chien2, Sih-Yen Wu2, Yu-Lin Wang2, Fu-Zen Shaw2, Yu-Hsing Huang2, Chi
ISSCC 2012
Session 17
Medical & Bio
A CMOS Impedance Cytometer for 3D Flowing Single-Cell Real-Time Analysis with ΔΣ Error Correction
and haematology for the diagnosis and prognosis of disease. It involves the counting, identification and sorting of cells [1,2]. Conventional bulk measurements [3] require a large volume of blood, which is not desirable
ISSCC 2012
Session 17
Medical & Bio
A mm-Sized Wirelessly Powered and Remotely Controlled Locomotive Implantable Device
Fully autonomous implantable systems with locomotion can revolutionize medical technology, and include applications ranging from diagnostics to minimally invasive surgery. However, the extreme power requirements of fluid
ISSCC 2012
Session 17
Medical & Bio
A 1V 5mA Multimode IEEE 802.15.6/Bluetooth Low-Energy WBAN Transceiver for Biotelemetry Applications loop filter is fully integrated and the synthesizer bandwidth is nominally 130kHz with in-band phase noise of -87dBc/Hz. The complete synthesizer current consumption is 2.5mA from a 1.0V supply.
Andreas Katsiamis, Oliver King, Franco Lauria, Johannes Schiff, Alison Burdett The 2.4GHz transmitter supports digital modulations of rotated π/2-DBPSK and π/4-DQPSK at a 600kHz symbol rate for the IEEE802.15.6 NB PHY dr
ISSCC 2012
Session 17
Medical & Bio
A Batteryless 19µW MICS/ISM-Band Energy Harvesting Body Area Sensor Node SoC
Manohar Nagaraju1, Alicia Klinefelter2, Jagdish Pandey1, James Boley2, Eric Carlson1, Aatmesh Shrivastava2, Brian Otis1, Benton Calhoun2 University of Washington, Seattle, WA University of Virginia, Charlottesville, VA 1
ISSCC 2012
Session 17
Medical & Bio
A Sub-10nA DC-Balanced Adaptive Stimulator IC with Multimodal Sensor for Compact Electro-Acupuncture System
stimulation, has been widely used for its effectiveness in pain relief since the 1970s [1] and later for treatment of various diseases such as depression, addiction, and gastrointestinal disorders [2], and non-medical ap
ISSCC 2012
Session 17
Medical & Bio
A 259.6µW Nonlinear HRV-EEG Chaos Processor with Body Channel Communication Interface for Mental Health Monitoring
Recently, there are many reports on the measurement of mental health conditions as derived from physiological parameters – see references in [1]. Usually, heart-rate or heart rate variability (HRV) has been used for moni
ISSCC 2012
Session 17
Medical & Bio
An 8-Channel Scalable EEG Acquisition SoC with Fully Integrated Patient-Specific Seizure Classification and Recording Processor
Institute of Technology, Cambridge, MA 4 Massachusetts General Hospital, Harvard Medical School, Cambridge, MA 5 KAIST, Daejeon, Korea 1 2 Tracking seizure activity to determine proper medication requires a small form fa
ISSCC 2011
Session 2
Medical & Bio
A Low-Power Fully Integrated RF Locked Loop for Miniature Atomic Clock
Very accurate local clocks play a fundamental role in modern communication and navigation applications. High-precision references enable fast communication data rates, while in navigation they allow longer holdover opera
ISSCC 2011
Session 2
Medical & Bio
A 660pW Multi-Stage Temperature-Compensated Timer for Ultra-Low-Power Wireless Sensor Node Synchronization
Fig. 2.7.5, left). The optimal configurations are determined and stored during post-silicon testing. Each time when the sensor node processor wakes up, it computes time by calculating the elapsed time using the stored pe
ISSCC 2011
Session 2
Medical & Bio
A Programmable Implantable Micro-Stimulator SoC with Wireless Telemetry: Application in Closed-Loop Endocardial Stimulation for Cardiac Pacemaker
C-M. Yang1, Y-Y. Chen2, H-Y. Lai3, J-W. Lin4, Q. Fang5 1 National Chung Cheng University, Chia-Yi, Taiwan, National Yang-Ming University, Taipei, Taiwan, 3 National Chiao Tung University, Hsinchu, Taiwan, 4 National Taiw
ISSCC 2011
Session 2
Medical & Bio
A Broadband THz Imager in a Low-Cost CMOS Technology
Dominique Coquillat2, Maciej Sakowicz2, Jean-Pierre Rostaing1, Michaël Tchagaspanian1, Benoît Giffard1, Wojciech Knap2 1 2 CEA-LETI-MINATEC, Grenoble, France, Université Montpellier 2 -CNRS UMR, Montpellier, France Terah
ISSCC 2011
Session 2
Medical & Bio
A 90nm CMOS SoC UWB Pulse Radar for Respiratory Rate Monitoring
UWB technology (3.1 to 10.6GHz) allows new applications for both data communication and sensing (FCC, reference in [1]). Due to their potential in terms of resolution and extremely low level of EIRP spectral density (< -
ISSCC 2011
Session 2
Medical & Bio
A 3µW Wirelessly Powered CMOS Glucose Sensor for an Active Contact Lens
The increase in the diabetes population makes glucose monitoring a pressing demand for clinical and continuous use. Non-invasive sensing would allow a painless, convenient solution compared to traditional skin-piercing g
ISSCC 2011
Session 2
Medical & Bio
A 75µW Real-Time Scalable Network Controller and a 25µW ExG Sensor IC for Compact Sleep-Monitoring Applications
Recently, a wearable body-sensor network realized continuous sleep monitoring by ExG (EEG, EMG, EOG, and ECG) extraction from a sleeper’s face [1]. At least 14 sensors were placed on the face, and were managed by a netwo
ISSCC 2011
Session 2
Medical & Bio
A 0.24nJ/b Wireless Body-Area-Network Transceiver with Scalable Double-FSK Modulation
health care and consumer electronic applications around the human body. There are 3 PHY schemes discussed in the IEEE 802.15.6 Task Group for WBAN standardization [1]: ultra-wide-band (UWB) PHY, narrow-band (NB) PHY, and
ISSCC 2011
Session 17
Medical & Bio
A 0.014mm2 9b Switched-Current DAC for AMOLED Mobile Display Drivers
amount of attention as a very desirable display due to superior characteristics such as its wide viewing angle, fast response, thinness, and low power consumption. Among various driving techniques for AMOLED displays, th
ISSCC 2011
Session 17
Medical & Bio
Bidirectional OLED Microdisplay: Combining Display and Image Sensor Functionality into a Monolithic CMOS Chip
light-emitting diodes (OLEDs) achieve high optical performance with excellent contrast ratio and large dynamic range at low power consumption. The direct light emission from the OLED enables small devices without additio
ISSCC 2011
Session 17
Medical & Bio
A 160×128 Single-Photon Image Sensor with On-Pixel 55ps 10b Time-to-Digital Converter
Day-Uey Li3, Matthew W Fishburn1, Yuki Maruyama1, David Stoppa4, Fausto Borghetti4, Marek Gersbach5, Robert K Henderson3, Edoardo Charbon1 1 Delft University of Technology, Delft, The Netherlands, STMicroelectronics, Edi
ISSCC 2011
Session 17
Medical & Bio
A Cubic-Millimeter Energy-Autonomous Wireless Intraocular Pressure Monitor
Yejoong Kim, Gyouho Kim, David Fick, Daeyeon Kim, Mingoo Seok, Kensall Wise, David Blaauw, Dennis Sylvester University of Michigan, Ann Arbor, MI Glaucoma is the leading cause of blindness, affecting 67 million people wo
ISSCC 2011
Session 17
Medical & Bio
A Low Noise Current Readout Architecture for Fluorescence Detection in Living Subjects
Natesh Parashurama1, Sanjiv S. Gambhir1, Bruce A. Wooley1 1 2 Stanford University, Stanford, CA, National Semiconductor, Santa Clara, CA Optical molecular imaging is emerging as a powerful preclinical research tool for i
ISSCC 2011
Session 17
Medical & Bio
A Neural Stimulator Front-End with Arbitrary Pulse
vitro arrays reached more than 10000 sites [1], implantable systems, e.g. for retinal [2,3] or cortical stimulation [4], have not exceeded above 1600 [5] – which was achieved with a reduction to basic functionality and w
ISSCC 2011
Session 17
Medical & Bio
An AC-Powered Optical Receiver Consuming 270µW for Transcutaneous 2Mb/s Data Transfer
Ulm, Germany, 3Intelligent Medical Implants, Bonn, Germany Improving communication with implantable systems remains an important topic of research due to the limitations in power dissipation and the simultaneous need for
ISSCC 2011
Session 17
Medical & Bio
A 0.013mm2 5µW DC-Coupled Neural Signal Acquisition IC with 0.5V Supply
interfaces has provided hope for patients with spinal-cord injuries, Parkinson’s disease, and other debilitating neurological conditions [1], and has boosted interest in electronic recording of cortical signals. State-of
ISSCC 2011
Session 17
Medical & Bio
A 10b Resistor-Resistor-String DAC with Current Compensation for Compact LCD Driver ICs
National Tsing Hua University, Hsinchu, Taiwan, National Chi Nan University, Puli, Taiwan, 3 University of California, Los Angeles, CA 2 Achieving a higher color depth for LCD drivers requires a higher DAC resolution and
ISSCC 2011
Session 17
Medical & Bio
A 160µW 8-Channel Active Electrode System for EEG Monitoring
2 imec - Holst Centre, Eindhoven, The Netherlands, Delft University of Technology, Delft, The Netherlands, 3imec, Leuven, Belgium An important drawback of current biopotential monitoring systems is their dependence on ge
ISSCC 2010
Session 6
Medical & Bio
A CMOS Electrochemical Impedance Spectroscopy Biosensor Array for Label-Free Biomolecular Detection
They take advantage of unique biomolecular interactions to capture and detect specific analytes on a surface. The detection versatility of biosensors has always been their key advantage and it has been demonstrated that
ISSCC 2010
Session 6
Medical & Bio
A Timing Controlled AC-DC Converter for Biomedical Implants Kim Fung Edward Lee
The magnetic source is inductively coupled to a coil inside the implant to induce an AC voltage, which is then further rectified to a DC voltage [1]. In general, higher supply voltages are often required for analog circu
ISSCC 2010
Session 6
Medical & Bio
A 1V 22µW 32-Channel Implantable EEG Recording IC
Epilepsy is one of the most common neurological disorders and affects more than 50 million individuals worldwide. Neurosurgery is an option for patients and intracranial EEG monitoring needs to be performed before surger
ISSCC 2010
Session 6
Medical & Bio
A 30µW Analog Signal Processor ASIC for Biomedical Signal Monitoring
U. Leuven, Leuven, Belgium 2 Power efficiency of readout circuits for ambulatory monitoring of biopotential signals has been significantly improved during recent years [1]-[3], leaving digital signal processing (DSP) and
ISSCC 2010
Session 6
Medical & Bio
A 20µW Neural Recording Tag with Supply-CurrentModulated AFE in 0.13µm CMOS
University of Florida, Gainesville, FL Perpetual measurement of brain activity in untethered small animal in-vivo experiments requires low power micro-systems incorporating amplification, A/D conversion, and short range
ISSCC 2010
Session 6
Medical & Bio
An Inductively Powered Scalable 32-Channel Wireless Neural Recording System-on-a-Chip for Neuroscience Applications
technology for interfacing with the central nervous system in laboratory animals and humans [1-2]. Even though these efforts have led to marvelous technological advancements in circuits and systems, some of the resulting
ISSCC 2010
Session 6
Medical & Bio
Stable RGBW AMOLED Display with OLED Degradation Compensation Using Electrical Feedback
College London, London, United Kingdom Here, ΔVLUM is f(ΔVOLED(i,j)), and Vp(i,j), Vdata(i,j) and Vmonitor(i,j) are the gray scale value and two programming values for data and monitor lines for the pixel at ith row and
ISSCC 2010
Session 6
Medical & Bio
A Double-Loop Control LED Backlight Driver IC for Medium-Sized LCDs
fluorescent lamp (CCFL) for LCD backlight units (BLU) for their lower power consumption, wider color gamut, and better dimming capability, in addition to being mercury-free [1, 2]. Recently, various studies have focused
ISSCC 2010
Session 6
Medical & Bio
A Mobile-Display-Driver IC Embedding a CapacitiveTouch-Screen Controller System
Kwang-Ho Choi, Hae-Yong Ahn, Jong-Kang Park, Dong-Yul Lee, Zhong-Yuan Wu, Hyung-Dal Kwon, Yong-Yeob Choi, Chang-Ju Lee, Hwa-Hyun Cho, Jae-Suk Yu, Myunghee Lee Samsung Electronics, Yongin, Korea Touch-screen technologies,
ISSCC 2010
Session 12
Medical & Bio
Compact Voltage and Current Stimulation Buffer for High-Density Microelectrode Arrays
ETH Zürich, Zürich, Switzerland ETH Zürich (now at IBM Research), Zürich, Switzerland 3 University of Tokyo, Tokyo, Japan 2 The most sophisticated information processing system, the human brain, consists of a huge number
ISSCC 2010
Session 12
Medical & Bio
An Implantable 5mW/Channel Dual-Wavelength Optogenetic Stimulator for Therapeutic Neuromodulation Research
technology of many neurological therapies, electrical stimulation suffers from several drawbacks. Constraints on electrode geometry and placement can result in an inability to modulate specific neural populations, and st
ISSCC 2010
Session 12
Medical & Bio
Mixed-Signal Integrated Circuits for Self-Contained Sub-Cubic Millimeter Biomedical Implants
Purdue University, West Lafayette, IN Texas Instruments, Dallas, TX 2 Development of fully wireless miniature implantable medical devices is challenging due to inefficiencies of electrically small antennas and tissue-ind
ISSCC 2010
Session 12
Medical & Bio
Pain Control On Demand Based on Pulsed RadioFrequency Stimulation of the Dorsal Root Ganglion Using a Batteryless Implantable CMOS SoC
I-Hsiu Ho2, Po Hsiang Fang1, Yi Chin Li1, Chang Lun Wang1, Yao-Chuan Tsai1, Yeong-Ray Wen3, Win-Pin Shih1, Yao-Joe Yang1, Shey-Shi Lu1 1 National Taiwan University, Taipei, Taiwan National Taipei University of Technology
ISSCC 2009
Session 25
Medical & Bio
A Frequency-Shift CMOS Magnetic Biosensor Array with Single-Bead Sensitivity and No External Magnet
Future Point-of-Care (PoC) molecular-level diagnosis requires advanced biosensing systems that can achieve high sensitivity and portability at low power consumption levels, all within a low price-tag for a variety of app
ISSCC 2009
Session 25
Medical & Bio
A CMOS Fluorescent-Based Biosensor Microarray
University of Texas, Austin, TX Biosensors are one of the most important analytical tools in biotechnology today. These detection systems take advantage of the selective interaction and binding of certain biological mole
ISSCC 2009
Session 25
Medical & Bio
A Biomedical Multiprocessor SoC for Closed-Loop Neuroprosthetic Applications
University of California, Santa Cruz, CA National Taiwan University, Taipei, Taiwan, 3Stanford University, Stanford, CA 2 Successful proof-of-concept laboratory experiments on cortically controlled motor prostheses [1],