ISSCC 2018
Session 29
Medical & Bio
A 16384-Electrode 1024-Channel Multimodal CMOS MEA for High-Throughput Intracellular Action Potential Measurements and Impedance Spectroscopy in Drug-Screening Applications
Jan Putzeys1, Carl Van Den Bulcke1,3, Jan-Willem Weijers1, Andrea Firrincieli1, Veerle Reumers1, Dries Braeken1, Nick Van Helleputte1 imec, Heverlee, Belgium Chrysalite, Tervuren, Belgium 3 KU Leuven, Leuven, Belgium 1 2
ISSCC 2018
Session 29
Medical & Bio
A Fully Immersible Deep-Brain Neural Probe with Modular Architecture and a Delta-Sigma ADC Integrated Under Each Electrode for Parallel Readout of 144 Recording Sites
tissue-penetrating probes for high-density deep-brain recording of in vivo neural activity is limited by the level of electronic integration on the probe shaft. As the number of electrodes increases, conventional devices
ISSCC 2018
Session 29
Medical & Bio
Creating Neural “Co-processors” to Explore Treatments for Neurological Disorders
Heather Orser1, Enrico Opri3, Vaclav Kremen2, Ben Brinkmann2, Aysegul Gunduz3, Kelly Foote3, Greg Worrell2, Tim Denison1 Medtronic Neurological Technology, Fridley, MN Mayo Clinic, Rochester, MN 3 University of Florida,
ISSCC 2017
Session 27
Medical & Bio
Fully Integrated Optical Spectrometer with 500-to-830nm Range in 65nm CMOS
Next-generation IoT systems are expected to be enabled by compact, low-cost, low-power, smart sensing devices that provide a wealth of information to build new applications and capabilities. Among sensing modalities, opt
ISSCC 2017
Session 27
Medical & Bio
A 30.5mm3 Fully Packaged Implantable Device with Duplex Ultrasonic Data and Power Links Achieving 95kb/s with <10-4 BER at 8.5cm Depth
invasive miniaturized solutions that operate reliably at large depths, provide duplex communication for closed-loop therapies, and enable multi-access for a network of implants to gather information or provide systemic i
ISSCC 2017
Session 27
Medical & Bio
Single-Chip 3072ch 2D Array IC with RX Analog and All-Digital TX Beamformer for 3D Ultrasound Imaging
Tatsuo Nakagawa2, Yasuyuki Okuma3, Yohei Nakamura2, Takahide Terada2, Yutaka Igarashi1, Taizo Yamawaki2, Toru Yazaki1, Yoshihiro Hayashi2, Kazuhiro Amino2, Takuya Kaneko2, Hiroki Tanaka2 Hitachi, Yokohama, Japan Hitachi,
ISSCC 2017
Session 27
Medical & Bio
A Pixel-Pitch-Matched Ultrasound Receiver for 3D Photoacoustic Imaging with Integrated Delta-Sigma Beamformer in 28nm UTBB FDSOI
in medical ultrasound rely on 3D volumetric imaging, calling for dense 2D transducer arrays with thousands of elements. Due to this high channel count, the traditional per-element cable interface used for 1D arrays is no
ISSCC 2017
Session 27
Medical & Bio
A Sub-1dB NF Dual-Channel On-Coil CMOS Receiver for Magnetic Resonance Imaging
Jonas Reber2, Josip Marjanovic2, Thomas Burger1, David O. Brunner2, Klaas P. Prüssmann2, Gerhard Tröster1, Qiuting Huang1 ETH Zurich, Zurich, Switzerland University and ETH Zurich, Zurich, Switzerland 1 2 Magnetic Resona
ISSCC 2017
Session 27
Medical & Bio
All-Wireless 64-Channel 0.013mm2/ch Closed-Loop Neurostimulator with Rail-to-Rail DC Offset Removal
M. Tariqus Salam3, Peter Carlen2,4, Jose Luiz Perez Velazquez2, Roman Genov2 York University, Toronto, Canada University of Toronto, Toronto, Canada 3 GSK (GlaxoSmithKline), Stevenage, United Kingdom 4 Toronto Western Ho
ISSCC 2017
Session 27
Medical & Bio
A 25.2mW EEG-NIRS Multimodal SoC for Accurate Anesthesia Depth Monitoring
monitoring of the quantitative anesthesia (ANES) depth level for safe surgery [1]. However, the current ANES depth monitoring approach, bispectral index (BIS) [3], uses only EEG from the frontal lobe, and it shows critic
ISSCC 2017
Session 27
Medical & Bio
A 2.8µW 80mVpp-Linear-Input-Range 1.6GΩ-Input Impedance Bio-Signal Chopper Amplifier Tolerant to Common-Mode Interference up to 650mVpp
Closed-loop neuromodulation with simultaneous stimulation and sensing is desired to administer therapy in patients suffering from drug-resistant neurological ailments. However, stimulation generates large artifacts at th
ISSCC 2016
Session 28
Medical & Bio
CMOS Monolithic Airborne-Particulate-Matter Detector Based on 32 Capacitive Sensors with a Resolution of 65zF rms
matter (PM) is well known [1]. Although optical and gravimetric instruments are available to detect PM, they lack portability, have poor potential for miniaturization, and are not low cost. Instead, a better spatio-tempo
ISSCC 2016
Session 28
Medical & Bio
A ±50mV Linear-Input-Range VCO-Based NeuralRecording Front-End with Digital Nonlinearity Correction
tool for understanding the brain and driving the progress in neuroscience research and therapy. The local field potential (LFP) signals, which span from 3Hz to about 200Hz, serve as indicators of various neurological beh
ISSCC 2016
Session 28
Medical & Bio
A 0.6V 0.015mm2 Time-Based Biomedical Readout for Ambulatory Applications in 40nm CMOS
applications in personal healthcare require sensor SoCs with low area, low power and a high dynamic range. Design in small-scale technologies can reduce the power and area of digital processing. However, due to the accom
ISSCC 2016
Session 28
Medical & Bio
A Battery-Powered Efficient Multi-Sensor
Mario Konijnenburg1, Stefano Stanzione1, Long Yan2, Dong-Woo Jee2, Julia Pettine1, Roland van Wegberg1, Hyejung Kim2, Chris van Liempd1, Ram Fish3, James Schluessler3, Harmke de Groot1, Chris van Hoof1,2, Refet Firat Yaz
ISSCC 2016
Session 28
Medical & Bio
CMOS Biosensor IC Focusing on Dielectric Relaxations of Biological Water with 120GHz and 60GHz Oscillator Arrays
are reduced to 0.07GHz (resp. 0.03GHz) if we exclude the 52 elements (resp. 44 elements) on the periphery that exhibit larger deviations due to the anisotropy of the layout. A selected 120GHz (resp. 60GHz) element draws
ISSCC 2016
Session 28
Medical & Bio
A 14GHz Battery-Operated Point-of-Care ESR Spectrometer Based on a 0.13µm CMOS ASIC
spatial distribution, and even dynamics of paramagnetic species, electron spin resonance (ESR) spectroscopy is one of the most powerful analytical techniques in modern life sciences. Recently, the method has gained signi
ISSCC 2016
Session 28
Medical & Bio
A Handheld 50pM-Sensitivity Micro-NMR CMOS Platform with B-Field Stabilization for Multi-Type Biological/Chemical Assays
Franco Maloberti2, Rui P. Martins1,4 University of Macau, Macau, China, University of Pavia, Pavia, Italy, 3 University of Glasgow, Glasgow, United Kingdom, 4 Instituto Superior Tecnico, Lisbon, Portugal 1 2 Point-of-use
ISSCC 2015
Session 21
Medical & Bio
A Wearable EEG-HEG-HRV Multimodal System with Real-Time tES Monitoring for Mental Health Management
based on EEG monitoring and transcranial electrical stimulation (tES)
ISSCC 2015
Session 21
Medical & Bio
A 16-ch Patient-Specific Seizure Onset and Termination Detection SoC with Machine-Learning and Voltage-Mode Transcranial Stimulation
Multichannel EEG seizure detection SoCs are widely used in medical practice and in research [1]-[3]. Due to huge variation in seizure patterns, patient-specific seizure detection is very crucial. [1], [2] presents 8-chan
ISSCC 2015
Session 21
Medical & Bio
A 0.036mbar Circadian and Cardiac Intraocular Pressure Sensor for Smart Implantable Lens
worldwide acknowledged to be the main leading cause of irreversible blindness. High intraocular pressure (IOP) is considered the leading risk factor for glaucoma. Lowering IOP continues to be the only evidence-based trea
ISSCC 2015
Session 21
Medical & Bio
A Smart CMOS Assay SoC for Rapid Blood Screening Test of Risk Prediction
Taiwan University Hospital, Taipei, Taiwan 1 2 Rapid blood test is essential to disease control, risk assessment and point-ofcare testing. Conventional enzyme-linked immunosorbent assay (ELISA) requires several hours or
ISSCC 2015
Session 21
Medical & Bio
A Portable Micro Gas Chromatography System for Volatile Compounds Detection with 15ppb of Sensitivity
Po-Hung Kuo, Yen-Ming Huang, Wei-Che Hsieh, Shih-An Yu, Yufeng Jane Tseng , Wei-Cheng Tian, Si-Chen Lee, Shey-Shi Lu National Taiwan Univeristy, Taipei, Taiwan Existing non-invasive lung cancer diagnostic equipment has d
ISSCC 2015
Session 21
Medical & Bio
A Microfluidic-CMOS Platform with 3D Capacitive Sensor and Fully Integrated Transceiver IC for Palmtop Dielectric Spectroscopy
Quantitative measurement of the complex relative dielectric permittivity (εr) of a material vs. frequency (i.e., dielectric spectroscopy, or DS) is a powerful monitoring technique that extracts key information on molecul
ISSCC 2015
Session 21
Medical & Bio
A 6.45µW Self-Powered IoT SoC with Integrated Energy-Harvesting Power Management and ULP Asymmetric Radios
Patricia Gonzalez1, Aatmesh Shrivastava1, Abhishek Roy1, Kyle Craig1, Muhammad Faisal2, James Boley1, Seunghyun Oh2, Yanqing Zhang1, Divya Akella1, David D. Wentzloff2, Benton H. Calhoun1 University of Virginia, Charlott
ISSCC 2015
Session 21
Medical & Bio
A 3nW Signal-Acquisition IC Integrating an Amplifier with 2.1 NEF and a 1.5fJ/conv-step ADC
unobtrusively wearable autonomous sensors, large sensor arrays, or wireless self-powered sensors, require a minuscule form factor and very low power consumption. For example, the power available from a state-of-the-art 1
ISSCC 2015
Session 21
Medical & Bio
A 79pJ/b 80Mb/s Full-Duplex Transceiver and a 42.5µW 100kb/s Super-Regenerative Transceiver for Body Channel Communication
video streaming and image data to be shared with friends while wearable smart sensors continuously monitor and send user’s physiological information to a smart watch. Body channel communication (BCC), which uses the huma
ISSCC 2014
Session 24
Medical & Bio
An Analog-Digital-Hybrid Single-Chip RX Beamformer with Non-Uniform Sampling for 2D-CMUT Ultrasound Imaging to Achieve Wide Dynamic Range of Delay and Small Chip Area
Min-Kyun Chae1, Jongkeun Song2, Baehyung Kim2, Seunghun Lee2, Jihoon Bang2, Youngil Kim2, Kyungil Cho2, Byungsub Kim1, Jae-Yoon Sim1, Hong-June Park1 Pohang University of Science and Technology, Pohang, Korea, Samsung Ad
ISSCC 2014
Session 24
Medical & Bio
A 60nV/√Hz 15-Channel Digital Active Electrode System for Portable Biopotential Signal Acquisition
electrodes (AE), i.e., the combination of dry electrodes with in situ amplification, are increasingly used for biopotential measurements in emerging healthcare and lifestyle applications [1]. Compared to gel-based wet el
ISSCC 2014
Session 24
Medical & Bio
A CMOS Micro-Flow Cytometer for Magnetic Label Detection and Classification
Ali M. Niknejad, Bernhard Boser University of California, Berkeley, CA Flow cytometry is widely used in medicine for hematology, immunology, chemotherapy and pathology, as well as in food and water safety. While present
ISSCC 2014
Session 24
Medical & Bio
A 0.5V 1.27mW Nose-on-a-Chip for Rapid Diagnosis of Ventilator-Associated Pneumonia
Chia-Ling Chang1, Chia-Min Yang1, Da-Jeng Yao1, Jen-Huo Wang1, Chien-Ming Huang1, Hsin Chen1, Kwuang-Han Chang1, Chih-Cheng Hsieh1, Ting-Hau Chang1, Meng-Fan Chang1, Chia-Min Wang1, Yi-Wen Liu1, Tsan-Jieh Chen3, Chia-Hsi
ISSCC 2014
Session 24
Medical & Bio
A 680nA Fully Integrated Implantable ECGAcquisition IC with Analog Feature Extraction
Leuven, Belgium 1 2 Ultra-low power consumption and miniature size are by far the most important design requirements for implantable pacemakers. In order to guarantee a long life span of the device, saving power in the s
ISSCC 2014
Session 24
Medical & Bio
An Implantable 64nW ECG-Monitoring Mixed-Signal SoC for Arrhythmia Diagnosis
Zhiyoong Foo1, Grant Kruger1, Hakan Oral2, Omer Berenfeld2, Zhengya Zhang1, David Blaauw1, Dennis Sylvester1 University of Michigan, Ann Arbor, MI, University of Michigan Health System, Ann Arbor, MI 1 2 Electrocardiogra
ISSCC 2014
Session 24
Medical & Bio
A Power-Efficient Switched-Capacitor Stimulating System for Electrical/Optical Deep-Brain Stimulation
Michigan State University, East Lansing, MI 1 2 Deep-brain stimulation (DBS) has been proven as an effective therapy to alleviate Parkinson’s disease, tremor, and dystonia. Towards a less invasive headmounted DBS, we uti
ISSCC 2014
Session 24
Medical & Bio
A Miniaturized 64-Channel 225µW Wireless Electrocorticographic Neural Sensor
Simone Gambini2, Toni Bjorninen3, Aaron Koralek1, Jose M. Carmena1, Michel M. Maharbiz1, Elad Alon1, Jan M. Rabaey1 University of California, Berkeley, CA, University of Melbourne, Parkville, Australia, 3 Tampere Univers
ISSCC 2014
Session 18
Medical & Bio
A Remotely Controlled Locomotive IC Driven by Electrolytic Bubbles and Wireless Powering
Taoyuan, Taiwan 1 As implantable medical CMOS devices become a reality [1], motion control of such implantable devices has become the next challenge in the advanced integrated micro-system domain. With integrated sensors
ISSCC 2014
Session 18
Medical & Bio
D Heterogeneously Integrated Bio-Sensing Microsystem for Multi-Channel Neural-Sensing Applications
Tang-Shuan Wang1, Yu-Rou Lin1, Chuan-An Cheng1, Wen-Wei Shen1, Kuan-Neng Chen1, Jin-Chern Chiou1,2, Ching-Te Chuang1, Wei Hwang1, Kuo-Hua Chen3, Chi-Tsung Chiu3, Ming-Hsiang Cheng3, Yueh-Lung Lin3, Ho-Ming Tong3 National
ISSCC 2014
Session 18
Medical & Bio
A 2.14mW EEG Neuro-Feedback Processor with Transcranial Electrical Stimulation for Mental-Health Management
therapy based on Quantitative EEG (QEEG) and Event Related Potential (ERP) online data measurements. The U.S. Food and Drug Administration (FDA) approved the first EEG test for diagnosing attention deficit hyperactivity
ISSCC 2014
Session 18
Medical & Bio
A 4.9mΩ-Sensitivity Mobile Electrical Impedance Tomography IC for Early Breast-Cancer Detection System
S. women will develop breast cancer over the course of her lifetime, and breast cancer death rates are higher than those for any other cancer, besides lung cancer. In 2013, an estimated 232,340 new cases of invasive brea
ISSCC 2014
Session 18
Medical & Bio
A Multi-Parameter Signal-Acquisition SoC for Connected Personal Health Applications DC-offset isn’t cancelled after the input differential pair of the gm-stage the proposed method doesn’t face the power vs. noise vs. DC-offset range trade-off from CFBIAs with DC-servos.
Dong-Woo Jee1, Arjan Breeschoten2, Alonso Morgado1, Tom Torfs1, Harmke de Groot2, Chris Van Hoof1, Refet Firat Yazicioglu1 Various very low power signal processors have been demonstrated [2]. This is usually achieved thr
ISSCC 2014
Session 18
Medical & Bio
A Fully-Implantable Cochlear Implant SoC with Piezoelectric Middle-Ear Sensor and Energy-Efficient Stimulation in 0.18µm HVCMOS
Konstantina M. Stankovic2,3, Anantha P. Chandrakasan1 Massachusetts Institute of Technology, Cambridge, MA, Harvard Medical School, Boston, MA, 3 Massachusetts Eye and Ear Infirmary, Boston, MA 1 2 A cochlear implant (CI
ISSCC 2014
Session 18
Medical & Bio
A 1V 3mA 2.4GHz Wireless Digital Audio Communication SoC for Hearing-Aid Applications in 0.18μm CMOS
Hearing aids are complex integrated and highly miniaturised systems based on digital signal processor and wireless communication chips. There is a growing need for wireless connectivity between hearing aids and external
ISSCC 2013
Session 6
Medical & Bio
Experimental Demonstration of a Fully Digital Capacitive Sensor Interface Built Entirely Using Carbon-Nanotube FETs
Georges Gielen2, H.-S. Philip Wong1, Subhasish Mitra1 Stanford University, Stanford, CA, KU Leuven, Heverlee, Belgium 1 2 Low-power applications, such as sensing, are becoming increasingly important and demanding in term
ISSCC 2013
Session 6
Medical & Bio
A 1024×8 700ps Time-Gated SPAD Line Sensor for Laser Raman Spectroscopy and LIBS in Space and Rover-Based Planetary Exploration
Jet Propulsion Laboratory, Pasadena, CA 1 2 Raman spectroscopy is a nondestructive, label-free optical analysis technique used to obtain structural and compositional information without any advance preparation. However,
ISSCC 2013
Session 6
Medical & Bio
An Organic VCO-Based ADC for Quasi-Static Signals Achieving 1LSB INL at 6b Resolution
read out using RFID protocols, are an important future application of large-area organic electronics. The first steps towards flexible organic electronics were code generators for RFID tags [1]. To realize flexible smart
ISSCC 2013
Session 6
Medical & Bio
A 4b ADC Manufactured in a Fully-Printed Organic Complementary Technology Including Resistors
of Technology, Eindhoven, The Netherlands, CEA-LITEN, Grenoble, France, 3 University of Catania, Catania, Italy, 4 STMicroelectronics, Catania, Italy 1 2 Organic transistors (OTFTs) can be printed on thin plastic substra
ISSCC 2013
Session 6
Medical & Bio
1µm-Thickness 64-Channel Surface Electromyogram Measurement Sheet with 2V Organic Transistors for Prosthetic Hand Control
Koichi Ishida1,2, Tomoyuki Yokota1,2, Naoji Matsuhisa1,2, Yusuke Inoue1,2, Masaki Sekino1,2, Tsuyoshi Sekitani1,2, Makoto Takamiya1,2, Takao Someya1,2, Takayasu Sakurai1,2 University of Tokyo, Tokyo, Japan, 2JST/ERATO, T
ISSCC 2013
Session 6
Medical & Bio
Through-Silicon-Via-Based Double-Side Integrated Microsystem for Neural Sensing Applications
Shih-Wei Lee1, Ching-Te Chuang1, Kuan-Neng Chen1, Jin-Chern Chiou1,2, Wei Hwang1,3, Yen-Chi Lee3, Chung-Hsi Wu3, Kuo-Hua Chen3, Chi-Tsung Chiu3, Ho-Ming Tong3 National Chiao Tung University, Hsinchu, Taiwan, 2 China Medi
ISSCC 2013
Session 6
Medical & Bio
A 1.83µJ/Classification Nonlinear Support-VectorMachine-Based Patient-Specific Seizure Classification SoC
To mitigate seizure-affected patients, SoCs [1-3] have been developed 1) to detect electrical onset of seizure seconds before the clinical onset, and 2) to combine the SoC with neurostimulation. In particular, having det
ISSCC 2013
Session 6
Medical & Bio
An 87mA·min Iontophoresis Controller IC with DualMode Impedance Sensor for Patch-Type Transdermal Drug Delivery System
Iontophoresis enhances drug penetration non-invasively into body tissue by electrical stimulation [1]. Compared with injection and oral dosage, it has advantages in the ease of use, the minimization of side effects, such