ISSCC 2021
Session 28
Medical & Bio
A 400mVpp 92.3dB-SNDR 1kHz-BW 2nd-Order VCO-Based ExG-to-Digital Front-End Using a Multiphase Gated-Inverted Ring-Oscillator Quantizer
Next-generation wearable devices will enable clinical-grade, continuous ExG (ECG, EEG, EMG, etc.) biopotential monitoring, providing medical professionals with valuable longitudinal data outside of hospital settings. The
ISSCC 2021
Session 28
Medical & Bio
A 28µW 134dB DR 2nd-Order Noise-Shaping Slope Light-to-Digital Converter for Chest PPG Monitoring 200µA. Since the DC-compensation information is available in the digital domain, the full-range signal can easily be reconstructed to derive the PI and blood oxygenation levels.
Dwaipayan Biswas1, Chris Van Hoof1,2, Filip Tavernier2, Nick Van Helleputte1 Figure 28.3.3 (right) shows the circuit implementation of the capacitor bank and the 3-T comparator within the NS loop. Since the input is a 10
ISSCC 2021
Session 28
Medical & Bio
A 400-to-1000nm 24µW Monolithic PPG Sensor with 0.3A/W Spectral Responsivity for Miniature Wearables
Hyelim Park, Taeyoul Jang, Haedo Jeong, Juhwa Kim, Jeongho Park, Raeyoung Kim, Jeonghoon Park, HeeJae Jo, Whee Jin Kim, Jangbeom Yang, Bongjin Sohn, Yuncheol Han, Inchun Lim, Seoungjae Yoo, Changsoon Park, Dae-geun Jang,
ISSCC 2021
Session 28
Medical & Bio
A Distortion-Free VCO-Based Sensor-to-Digital Front-End Achieving 178.9dB FoM and 128dB SFDR with a CalibrationFree Differential Pulse-Code Modulation Technique
Motion and stimulation artifacts encountered in wearable sensors present difficult dynamic range (DR) and linearity challenges: AFEs need to be able to resolve μV-level signals in the presence of artifacts up to 100s of
ISSCC 2021
Session 18
Medical & Bio
A Wireless Multimodality System-on-a-Chip with Time-Based Resolution Scaling Technique for Chronic Wound Monitoring
wounds (CWs) may last for weeks or even months. The process of CW healing relies on many highly regulated factors, such as C-reactive protein (CRP), uric acid (UA), and temperature, which require in-depth observations. R
ISSCC 2021
Session 18
Medical & Bio
An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution efficiency and loop gain. A smaller VGS reduces the conduction angle in the large-signal operation for better energy efficiency while compromising the loop gain at startup. With 0.5V VGS, the simulated efficiency is >45%, and the loop gain is >2.3 across the entire frequency tuning range.
the fourth row of the array and capacitively coupled to the oscillator outputs. The measured maximum RF swing is >19.5Vpp for the four-stacked oscillator and >26.5Vpp for the five-stacked oscillator from 1.44 to 1.95GHz
ISSCC 2021
Session 18
Medical & Bio
CMOS-Driven Pneumatic-Free Scalable Microfluidics and Fluid Processing with Label-Free Cellular and Bio-Molecular Sensing Capability for an End-to-End Point-of-Care System
point-of-care (POC) molecular diagnostic platforms that encompass an end-to-end system (from sample fluid to diagnostic information) with the ability to allow rapid analysis on the spot. While POC sensing technologies ha
ISSCC 2021
Session 18
Medical & Bio
An Optically-Addressed Nanowire-Based Retinal Prosthesis with 73% RF-to-Stimulation Power Efficiency and 20nC-to-3µC Wireless Charge Telemetering
Patrick P. Mercier1, Gert Cauwenberghs1 University of California, San Diego, La Jolla, CA KAIST, Daejeon, Korea 3 Nanovision Biosciences, San Diego, CA 1 2 Recent approaches toward a functional retinal prosthesis to rest
ISSCC 2020
Session 34
Medical & Bio
EEG Dust: A BCC-Based Wireless Concurrent Recording/Transmitting Concentric Electrode
Institute for Health, Singapore, Singapore 1 2 EEG recording technology creates the opportunity to sense and discover potential fluctuation in the human brain [1]. Quantitative analysis based on various EEG sensor nodes
ISSCC 2020
Session 34
Medical & Bio
Human-Body-Coupled Power-Delivery and AmbientEnergy-Harvesting ICs for a Full-Body-Area Power Sustainability is performed for bulk connection with the VRECT and GND at input amplitude higher than 0.6V, so that the body diode forward biasing is aligned with the conduction path. As a result, at 5V TX swing, 3.5μW power is recovered from ankle to forehead (160cm), successfully covering the whole body.
Miaolin Zhang1, Han Wu1, Lian Zhang1, Joanne Si Ying Tan1, Jerald Yoo1,2 Figure 34.5.4 shows the proposed Dual-Mode Buck-Boost Converter (DM-BBC). Due to the unpredictability of the environmental parasitic and the variat
ISSCC 2020
Session 34
Medical & Bio
A 4.5mm3 Deep-Tissue Ultrasonic Implantable Luminescence Oxygen Sensor
Continuous monitoring of regional tissue oxygenation (RTO) can provide therapeutic guidance for critical care patients. Current technologies for RTO assessment require tethered, wired connections or batteries, creating p
ISSCC 2020
Session 34
Medical & Bio
An 8.2mm3 Implantable Neurostimulator with Magnetoelectric Power and Data Transfer
Amanda Singer, Jacob T. Robinson, Kaiyuan Yang Rice University, Houston, TX *Equally-Credited Authors (ECAs) Modulating the electrical activity in the nervous system has shown great potential for neuroscience research an
ISSCC 2020
Session 34
Medical & Bio
A 64×64 Implantable Real-Time Single-ChargedParticle Radiation Detector for Cancer Therapy
Kavita K. Mishra2, Bruce A. Faddegon2, Michel M. Maharbiz1, Mekhail Anwar2 University of California, Berkeley, CA 2 University of California, San Francisco, CA 1 60% of all cancer treatment requires radiation therapy and
ISSCC 2020
Session 28
Medical & Bio
A CMOS Multimodality In-Pixel Electrochemical and Impedance Cellular Sensing Array for Massively Paralleled Synthetic Exoelectrogen Characterization current/charge-transfer with CV and CA tests. The generated current from cell samples is integrated on the feedback capacitor (50 to 150fF) of the in-pixel capacitive-TIA (CTIA), and 2-point measurements extract the output integration slope to remove flicker noise and fixed pattern noise.
Sara Tejedor Sanz3, Sandra Grijalva4, Adam Wang1, Sensen Li1, Hee Cheol Cho4, Caroline Ajo-Franklin5, Hua Wang1 The complex cellular impedance sensing circuit is illustrated in Fig. 28.4.3. The two WEs in each pixel oper
ISSCC 2020
Session 28
Medical & Bio
A 5.2Mpixel 88.4dB-DR 12in CMOS X-Ray Detector with 16b Column-Parallel Continuous-Time ΔΣ ADCs
a full image depth even for a specific region of interest, and require high resolution, low noise, and wide DR in a wafer-scale detector [1-4]. To achieve a wide DR, a large integration capacitor is required within the p
ISSCC 2020
Session 28
Medical & Bio
A 51dB-SNR 120Hz-Scan-Rate 32×18 Segmented-VCOM LCD In-Cell Touch-Display-Driver IC with 96-Channel Compact Shunt-Sensing Self-Capacitance Analog Front-End
display implementation have been undertaken in recent years, with several being successfully delivered to the industry and market. As a result, in-cell touch-display solutions that offer low-profile formfactor, low modul
ISSCC 2020
Session 28
Medical & Bio
A Capacitive Touch Chipset with 33.9dB ChargeOverflow Reduction Using Amplitude-Modulated Multi-Frequency Excitation and Wireless Power and Data Transfer to an Active Stylus
systems (CTSs), several driving methods have been reported [1-5]. However, when excitation circuits simultaneously send excitation signals (VEXTs) to multiple TX electrodes in order to increase frame rate, the readout ci
ISSCC 2020
Session 26
Medical & Bio
A 0.19×0.17mm2 Wireless Neural Recording IC for Motor Prediction with Near-Infrared-Based Power and Data Telemetry
Paras R. Patel1, Parag G. Patil1, Sechang Oh1, Inhee Lee1, Hun-Seok Kim1, Dennis Sylvester1, David Blaauw1, Cynthia A. Chestek1, Jamie Phillips1, Taekwang Jang2 University of Michigan, Ann Arbor, MI ETH Zürich, Zürich, S
ISSCC 2020
Session 26
Medical & Bio
A Trimodal Wireless Implantable Neural Interface System-on-Chip
5Bionic Sciences, Atlanta, GA 1 3 Implantable biomedical devices (IMDs) capable of injecting a designated current into target neural tissue to modulate neural activity have been proven therapeutically effective. The next
ISSCC 2020
Session 26
Medical & Bio
A 280µW 108dB DR Readout IC with Wireless Capacitive Powering Using a Dual-Output Regulating Rectifier for Implantable PPG Recording
The development of advanced neuroprostheses for restoration of function after spinal cord injury (SCI) is one of the most rapidly growing directions for neuroengineering research. Among the most exciting solutions is a n
ISSCC 2020
Session 26
Medical & Bio
A 6.5µW 10kHz-BW 80.4dB-SNDR Continuous-Time ΔΣ Modulator with Gm-Input and 300mVpp Linear Input Range for Closed-Loop Neural Recording
Kwandong University International St. Mary’s Hospital, Incheon, Korea 1 2 Closed-loop neural recording requires a front-end with a wide DR to record small neural signals without distortion in the presence of a DC electro
ISSCC 2020
Session 26
Medical & Bio
A 20µW Heartbeat Detection System-on-Chip Powered by Human Body Heat for Self-Sustaining Wearable Healthcare
*Equally-Credited Authors (ECAs) Wearable devices are expanding beyond consumer and entertainment applications, including continuous monitoring of vital signs for medical diagnostics, due to extended ambulatory measureme
ISSCC 2020
Session 26
Medical & Bio
A Cell-Capacitance-Insensitive CMOS Sample-and-Hold Chronoamperometric Sensor for Real-Time Measurement of Small Molecule Drugs in Whole Blood exponential model). Most of the signal-of-interest lies within the first 10ms after the potential stepping, indicating that the ADC can be further powered off during the other 90ms. The sensor front-end is configured to perform SWV calibration every few tens of minutes to track drift in the redox potential.
with a tail current of 320µA are employed in the DAC reference buffer, the current conveyor, and the potentiostat. The Miller-compensated RC network in the potentiostat is removed to avoid instability. To minimize leakag
ISSCC 2020
Session 26
Medical & Bio
A Closed-Loop Neuromodulation Chipset with 2-Level Classification Achieving 1.5Vpp CM Interference
Aerosemi Technology, Xi'an, China 1 2 In closed-loop neuromodulators for epilepsy patients, nonidealities such as common-mode interference (CMI), stimulation artifacts (SA), electrode DC offset (DCO) and 1/f noise bring
ISSCC 2019
Session 22
Medical & Bio
Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications
David Groppe2, Xuan-Thuan Nguyen1, Karim Abdelhalim1, 3, Hamed Mazhab Jafari1,4, Taufik A. Valiante5, Peter Carlen5, Naveen Verma6, Roman Genov1 *1 *1 2 University of Toronto, Toronto, Canada Krembil Neuroscience Center,
ISSCC 2019
Session 22
Medical & Bio
A Programmable Wireless EEG Monitoring SoC with Open/Closed-Loop Optogenetic and Electrical Stimulation for Epilepsy Control
stimulation systems [1-2] for efficient control of neurological disorders is increasing, because recent clinical studies have shown their efficiency and usefulness in symptom suppression. Electrical stimulation can produce
ISSCC 2019
Session 22
Medical & Bio
A 13-Channel 1.53-mW 11.28-mm2 Electrical Impedance Tomography SoC Based on Frequency Division Multiplexing with 10× Throughput Reduction
has been reported as the only viable wearable real-time method for lung imaging [1]. Previous EIT chips generally employ Time-Division Multiplexing (TDM) or as active electrode to facilitate multichannel read-out [2-4],
ISSCC 2019
Session 22
Medical & Bio
A Bio-Impedance Readout IC with Digital-Assisted Baseline Cancellation for 2-Electrode Measurement
KU Leuven, Heverlee, Belgium Figure 22.5.3 compares the measured noise performance with and without baseline cancellation. All noise numbers are measured by applying a current to a known resistor and taking the digital o
ISSCC 2019
Session 22
Medical & Bio
A 27.8μW Biopotential Amplifier Tolerant to 30Vpp Common-Mode Interference for Two-Electrode ECG Recording in 0.18μm CMOS
Two-electrode ECG devices have gained popularity in the recent past to enable comfortable and long-term monitoring of cardiovascular health. As a ground or bias electrode is not used in a two-electrode ECG device, common
ISSCC 2019
Session 22
Medical & Bio
A 0.5V 9.26µW 15.28mΩ/√Hz Bio-Impedance Sensor IC with 0.55° Overall Phase Error
measurement [1] is critical in reducing chronic heart failure (CHF) because the symptoms of deterioration are not recognized by patients, thus preventing timely treatment. Therefore, a wearable/implantable bio-impedance
ISSCC 2019
Session 22
Medical & Bio
A Rugged Wearable Modular ExG Platform Employing a Distributed Scalable Multi-Channel FM-ADC Achieving 101dB Input Dynamic Range and Motion-Artifact Resilience
University of California, San Diego, La Jolla, CA MaXentric Technologies, La Jolla, CA 1 2 Wearable ExG biopotential acquisition systems can potentially capture a wealth of clinically useful diagnostic information during
ISSCC 2019
Session 22
Medical & Bio
A 769µW Battery-Powered Single-Chip SoC with BLE for Multi-Modal Vital Sign Health Patches
Hyunsoo Ha1, Wim Sijbers2, Jiawei Xu1, Stefano Stanzione1, Chris van Liempd1, Dwaipayan Biswas2, Arjan Breeschoten1, Peter Vis1, Chris Van Hoof1,2,3, Nick Van Helleputte2 imec - Netherlands, Eindhoven, The Netherlands im
ISSCC 2019
Session 17
Medical & Bio
A 2.6µW Monolithic CMOS Photoplethysmographic Sensor Operating with 2µW LED Power
Photoplethysmography (PPG) is a key technology allowing non-invasive monitoring of vital indicators such as heart rate (HR) and oxygen saturation (SpO2). Today, the total PPG sensor power consumption is dominated by the
ISSCC 2019
Session 17
Medical & Bio
A 7.0fps Optical and Electrical Dual Tomographic Imaging SoC for Skin-Disease Diagnosis System
million cases of skin cancer were treated in over 3.3 million people in the U.S. in 2012, and more people are diagnosed with skin cancer each year than all other cancers combined in the U.S. [1]. Because a malignant lesi
ISSCC 2019
Session 17
Medical & Bio
A Sub-40µW 5Mb/s Magnetic Human Body Communication Transceiver Demonstrating Trans-Body Delivery of High-Fidelity Audio to a Wearable In-Ear Headphone
Emerging wearable devices such as wireless headphones, smart glasses, and medical monitors require increasingly high-throughput wireless communications at ultra-low-power. Since far-field RF has significant path loss aroun
ISSCC 2019
Session 17
Medical & Bio
A 0.8mm3 Ultrasonic Implantable Wireless Neural Recording System with Linear AM Backscattering
Sina Faraji Alamouti, Cem Yalcin, Benjamin C. Johnson, Jose M. Carmena, Michel M. Maharbiz, Rikky Muller University of California, Berkeley, CA Miniaturization of implantable neural recording systems to micron-scale volu
ISSCC 2019
Session 17
Medical & Bio
16MHz FRAM Micro-Controller with a Low-Cost Sub-1μA Embedded Piezo-Electric Strain Sensor for ULP Motion Detection
Nagaraj Krishnasawamy1, Hadi Najar2, Suman Bellary2, Wei-Yan Shih1, Scott Summerfelt1, Steven Bartling1 Texas Instruments, Dallas, TX Texas Instruments, Santa Clara, CA 1 2 Ultra-low Power Microcontrollers (MCUs) [1-4] h
ISSCC 2019
Session 17
Medical & Bio
Hybrid System for Efficient LAE-CMOS Interfacing in Large-Scale Tactile-Sensing Skins via TFT-Based Compressed Sensing
Sigurd Wagner, James C. Sturm, Naveen Verma Princeton University, Princeton, NJ *Equally-Credited Authors (ECAs) Tactile sensing has wide-ranging applications, from intelligent surfaces to advanced robotics. Large-Area E
ISSCC 2019
Session 17
Medical & Bio
A 142nW Voice and Acoustic Activity Detection Chip for mm-Scale Sensor Nodes Using Time-Interleaved MixerBased Frequency Scanning
one of the most widely used sensing modalities to intelligently assess the environment. In particular, ultra-low power (ULP) always-on voice activity detection (VAD) is gaining attention as an enabling technology for IoT
ISSCC 2019
Session 17
Medical & Bio
AI x Robotics: Technology Challenges and Opportunities
(AI) was first used. In those days it was also called as symbolic AI (Symbolic-AI) [1]. For example, let us assume a block world problem in Fig 17.1.1 (right), where a block is represented as a symbol, “Block1”, and it ca
ISSCC 2019
Session 11
Medical & Bio
A 512-Pixel 3kHz-Frame-Rate Dual-Shank Lensless Filterless Single-Photon-Avalanche-Diode CMOS Neural Imaging Probe
Laurent Moreaux3, Michael L. Roukes3, Kenneth L. Shepard1 Columbia University, New York, NY KIST, Seoul, Korea 3 California Institute of Technology, Pasadena 1 out of Geiger mode after sufficient decay of the fluorescent s
ISSCC 2019
Session 11
Medical & Bio
A Fast-Readout Mismatch-Insensitive Magnetoresistive Biosensor Front-End Achieving Sub-ppm Sensitivity
Magnetic biosensors have drawn significant research interest as a means to replace large optical instrumentation commonly found in centralized diagnostic laboratories. Magnetic biosensing is attractive since biological sa
ISSCC 2019
Session 11
Medical & Bio
A Capacitive Biosensor for Cancer Diagnosis Using a Functionalized Microneedle and a 13.7b-Resolution Capacitance-to-Digital Converter from 1 to 100nF
dedicated blood supply to provide oxygen and nutrients. Therefore, vascular endothelial growth factor (VEGF), a signal protein produced by cells stimulating angiogenesis, is considered as a key biomarker in clinical diag
ISSCC 2019
Session 11
Medical & Bio
A CMOS Biosensor Array with 1024 3-Electrode Voltammetry Pixels and 93dB Dynamic Range
Rituraj Singh1, Nader Gamini1, Davood Shahrjerdi2, Robert G. Kuimelis1, Arjang Hassibi1 InSilixa, Sunnyvale, CA New York University, New York, NY 1 2 Electro-analytical (E-chem) biosensors offer unique advantages over wi
ISSCC 2019
Session 11
Medical & Bio
A 5.37mW/Channel Pitch-Matched Ultrasound ASIC with Dynamic-Bit-Shared SAR ADC and 13.2V Charge-Recycling TX in Standard CMOS for Intracardiac Echocardiography
Institute for Neurotechnology, Singapore, Singapore 1 2 Intracardiac echocardiography (ICE) is an ultrasound sonogram that visualizes the anatomical structure of the heart in real time, with a mm-scale catheter inserted
ISSCC 2018
Session 29
Medical & Bio
A 43.4μW Photoplethysmogram-Based Heart-Rate Sensor Using Heart-Beat-Locked Loop
Photoplethysmogram (PPG) sensors have gained great popularity in recent years as they can easily obtain heart rate (HR) in wearable devices such as smart watches and smart rings. However, one of the biggest problems for
ISSCC 2018
Session 29
Medical & Bio
A 110dB-CMRR 100dB-PSRR Multi-Channel NeuralRecording Amplifier System Using Differentially Regulated Rejection Ratio Enhancement in 0.18μm CMOS
Korea 4 Korea Institute of Science and Technology, Seoul, Korea 5 Seoul National University of Science and Technology, Seoul, Korea rails of the amplifier stack, VDD_LNA, VMID and VSS_LNA also tracks VCM, effectively sup
ISSCC 2018
Session 29
Medical & Bio
A 92dB Dynamic Range Sub-μVrms-Noise 0.8μW/ch Neural-Recording ADC Array with Predictive Digital Autoranging
center left). A two-stage comparator (Fig. 29.6.2 top right) performs 1b quantization. Decision time ranges from 1.5 to 2μs depending on input amplitude, dominated by capacitive loading (CT = 20fF) of the first-stage cur
ISSCC 2018
Session 29
Medical & Bio
A mm-Sized Free-Floating Wirelessly Powered Implantable Optical Stimulating System-on-a-Chip
cell-type specificity, high spatiotemporal precision, and reversibility, optogenetic neuromodulation has been widely utilized in brain mapping, visual prostheses, psychological disorders, Parkinson's disease, epilepsy, a
ISSCC 2018
Session 29
Medical & Bio
A 0.13μm CMOS SoC for Simultaneous Multichannel Optogenetics and Electrophysiological Brain Recording
approaches in neuroscience to observe neural microcircuits in vivo [1]. Thereby, brain-implantable devices incorporating optical stimulation and low-noise data acquisition means have been designed based on custom integra